Fischer L et al, 2004

Effects of Soy Isoflavone Supplementation in Prostate Cancer Patients

A study investigated the effects of soy isoflavone supplementation in 20 males with prostate cancer (stages B, C, or D), aged 53–82 years (19 Caucasians, 1 African American). Three subjects dropped out, leaving 17 participants. The supplementation regimen included:

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• 398 mg/day for 28 days

• 796 mg/day for 56 days

• Total duration: 84 days

Key Observations:

• Breast changes were observed, likely due to the estrogenic effects of soy isoflavones.

• Increased frequency of hot flushes, a symptom commonly associated with hormonal fluctuations.

DNA Damage Assessment (Comet Assay on Peripheral Lymphocytes):​

• No observed rearrangements in MLL genes, indicating that the test diet did not induce major genetic alterations linked to leukaemia or other malignancies.

Implications:

These findings suggest that soy isoflavones may influence hormonal symptoms in men with prostate cancer, possibly due to their oestrogen-like activity.

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Citation : Fischer L, Mahoney C, Jeffcoat AR, Koch MA, Thomas BF, Valentine JL, Stinchcombe T,Boan J, Crowell JA, Zeisel SH. Clinical characteristics and pharmacokinetics of purifiedsoy isoflavones: multiple-dose administration to men with prostate neoclassic, Nutr.Cancer (2004) 48: 160-170